RegPep2018 Proceedings 1 in 2: Frontiers in Neuroendocrine Science

Editorial: Regulatory Peptides in Neuroscience and Endocrinology: A New Era Begins

Limei Zhang , David Vaudry , Colin H. Brown and Lee E. Eiden

Editorial

Published on 04 December 2019
Front. Endocrinol. doi: 10.3389/fendo.2019.00793

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Conceptualization of a Parasympathetic Endocrine System

Jonathan Gorky and James Schwaber

Hypothesis and TheoryWe here propose a parasympathetic endocrine system (PES) comprised of circulating peptides released from secretory cells in the gut, significantly modulated by vagal projections from the dorsal motor nucleus of the vagus (DMV). While most of these …

Published on 23 September 2019
Front. Neurosci. doi: 10.3389/fnins.2019.01008

 

Synthetic Peptides as Therapeutic Agents: Lessons Learned From Evolutionary Ancient Peptides and Their Transit Across Blood-Brain Barriers

David A. Lovejoy , David W. Hogg, Thomas L. Dodsworth , Fernando R. Jurado, Casey C. Read, Andrea L. D’Aquila and Dalia Barsyte-Lovejoy

Hypothesis and TheoryPeptides play a major role in the transmission of information to and from the central nervous system. However, because of their structural complexity, the development of pharmacological peptide-based therapeutics has been challenged by the lack of …

Published on 12 November 2019
Front. Endocrinol. doi: 10.3389/fendo.2019.00730

 

Sex Dimorphic Responses of the Hypothalamus–Pituitary–Thyroid Axis to Maternal Separation and Palatable Diet

Lorraine Jaimes-Hoy , Fidelia Romero , Jean-Louis Charli and Patricia Joseph-Bravo

Original ResearchNeonatal stress contributes to the development of obesity and has long-lasting effects on elements of the hypothalamus–pituitary–thyroid (HPT) axis. Given the importance of thyroid hormones in metabolic regulation, we studied the effects of maternal …

Published on 11 July 2019
Front. Endocrinol. doi: 10.3389/fendo.2019.00445

 

Whole-Brain Mapping of Monosynaptic Afferent Inputs to Cortical CRH Neurons

Shouhua Zhang , Fei Lv , Yuan Yuan , Chengyu Fan , Jiang Li , Wenzhi Sun and Ji Hu

Original ResearchCorticotropin-releasing hormone (CRH) is a critical neuropeptide modulating the mammalian stress response. It is involved in many functional activities within various brain regions, among which there is a subset of CRH neurons occupying a …

Published on 04 June 2019
Front. Neurosci. doi: 10.3389/fnins.2019.00565

 

Voluntary Exercise-Induced Activation of Thyroid Axis and Reduction of White Fat Depots Is Attenuated by Chronic Stress in a Sex Dimorphic Pattern in Adult Rats

Marco Antonio Parra-Montes de Oca , Mariana Gutiérrez-Mariscal, Ma Félix Salmerón-Jiménez, Lorraine Jaimes-Hoy , Jean-Louis Charli and Patricia Joseph-Bravo

Original ResearchThe activity of the hypothalamus-pituitary-thyroid (HPT) axis is inhibited by energy deficit, by acute or chronic stress, but activated by cold exposure or exercise. Because stress curtails acute cold induced activation of HPT, we evaluated the …

Published on 26 June 2019
Front. Endocrinol. doi: 10.3389/fendo.2019.00418

 

Effect of Oxytocin on Hunger Discrimination

Mitchell A. Head , David C. Jewett, Sarah N. Gartner , Anica Klockars , Allen S. Levine and Pawel K. Olszewski

Original ResearchCentrally and peripherally administered oxytocin (OT) decreases food intake and activation of the endogenous OT systems, which is associated with termination of feeding. Evidence gathered thus far points to OT as a facilitator of early satiation, a …

Published on 15 May 2019
Front. Endocrinol. doi: 10.3389/fendo.2019.00297

 

Involvement of Vasopressin in the Pathogenesis of Pulmonary Tuberculosis: A New Therapeutic Target?

Mario Zetter , Jorge Barrios-Payán , Dulce Mata-Espinosa , Brenda Marquina-Castillo , Andrés Quintanar-Stephano and Rogelio Hernández-Pando

Original ResearchTuberculosis (TB) is a highly complex infectious disease caused by the intracellular pathogen Mycobacterium tuberculosis (Mtb). It is characterized by chronic granulomatous inflammation of the lung and systemic immune–neuroendocrine responses that …

Published on 06 June 2019
Front. Endocrinol. doi: 10.3389/fendo.2019.00351

 

Spexin-Based Galanin Receptor Type 2 Agonist for Comorbid Mood Disorders and Abnormal Body Weight

Seongsik Yun, Arfaxad Reyes-Alcaraz, Yoo-Na Lee, Hyo Jeong Yong, Jeewon Choi, Byung-Joo Ham , Jong-Woo Sohn , Dong-Hoon Kim , Gi Hoon Son , Hyun Kim , Soon-Gu Kwon, Dong Sik Kim, Bong Chul Kim, Jong-Ik Hwang and Jae Young Seong

Original ResearchDespite the established comorbidity between mood disorders and abnormal eating behaviors, the underlying molecular mechanism and therapeutics remain to be resolved. Here, we show that a spexin-based galanin receptor type 2 agonist (SG2A) …

Published on 18 April 2019
Front. Neurosci. doi: 10.3389/fnins.2019.00391

 

A Synaptically Connected Hypothalamic Magnocellular Vasopressin-Locus Coeruleus Neuronal Circuit and Its Plasticity in Response to Emotional and Physiological Stress

Oscar R. Hernández-Pérez , Vito S. Hernández , Alicia T. Nava-Kopp , Rafael A. Barrio , Mohsen Seifi , Jerome D. Swinny , Lee E. Eiden and Limei Zhang

Original ResearchThe locus coeruleus (LC)-norepinephrine (NE) system modulates a range of salient brain functions, including memory and response to stress. The LC-NE system is regulated by neurochemically diverse inputs, including a range of neuropeptides such as …

Published on 20 March 2019
Front. Neurosci. doi: 10.3389/fnins.2019.00196

 

The Roles of the Kisspeptin System in the Reproductive Physiology of the Lined Seahorse (Hippocampus erectus), an Ovoviviparous Fish With Male Pregnancy

Huixian Zhang , Bo Zhang, Geng Qin, Shuisheng Li and Qiang Lin

Original ResearchThe kisspeptin/GPR54 system plays a crucial role in the regulation of the reproductive axis in vertebrates. Male pregnancy and ovoviviparity are special reproductive phenomena among vertebrates. To better understand the neuroendocrine mechanisms of …

Published on 11 December 2018
Front. Neurosci. doi: 10.3389/fnins.2018.00940

 

Dynamic Modulation of Mouse Locus Coeruleus Neurons by Vasopressin 1a and 1b Receptors

Elba Campos-Lira , Louise Kelly , Mohsen Seifi , Torquil Jackson , Torsten Giesecke , Kerim Mutig , Taka-aki A. Koshimizu , Vito S. Hernandez , Limei Zhang and Jerome D. Swinny

Original ResearchThe locus coeruleus (LC) is a brainstem nucleus distinguished by its supply of noradrenaline throughout the central nervous system. Apart from modulating a range of brain functions, such as arousal, cognition and the stress response, LC neuronal …

Published on 10 December 2018
Front. Neurosci. doi: 10.3389/fnins.2018.00919

 

Deletion of CRH From GABAergic Forebrain Neurons Promotes Stress Resilience and Dampens Stress-Induced Changes in Neuronal Activity

Nina Dedic , Claudia Kühne, Karina S. Gomes , Jakob Hartmann , Kerry J. Ressler, Mathias V. Schmidt and Jan M. Deussing

Original ResearchDysregulation of the corticotropin-releasing hormone (CRH) system has been implicated in stress-related psychopathologies such as depression and anxiety. Although most studies have linked CRH/CRH receptor 1 signaling to aversive, stress-like …

Published on 20 September 2019
Front. Neurosci. doi: 10.3389/fnins.2019.00986

 

Pituitary Adenylate Cyclase-Activating Peptide (PACAP)-Glutamate Co-transmission Drives Circadian Phase-Advancing Responses to Intrinsically Photosensitive Retinal Ganglion Cell Projections by Suprachiasmatic Nucleus

Peder T. Lindberg , Jennifer W. Mitchell , Penny W. Burgoon , Christian Beaulé , Eberhard Weihe , Martin K.-H. Schäfer , Lee E. Eiden , Sunny Z. Jiang and Martha U. Gillette

Original ResearchResults from a variety of sources indicate a role for pituitary adenylate cyclase-activating polypeptide (PACAP) in light/glutamate-induced phase resetting of the circadian clock mediated by the retinohypothalamic tract (RHT). Attempts to block or …

Published on 06 December 2019
Front. Neurosci. doi: 10.3389/fnins.2019.01281

Strategies for the Identification of Bioactive Neuropeptides in Vertebrates

Auriane Corbière , Hubert Vaudry , Philippe Chan, Marie-Laure Walet-Balieu, Thierry Lecroq , Arnaud Lefebvre , Charles Pineau and David Vaudry

ReviewNeuropeptides exert essential functions in animal physiology by controlling e.g., reproduction, development, growth, energy homeostasis, cardiovascular activity and stress response. Thus, identification of neuropeptides has been a very active field …

Published on 18 September 2019
Front. Neurosci. doi: 10.3389/fnins.2019.00948